The Trial of Chloroquine in the Treatment of Corona Virus Disease 2019 （COVID-19） and Its Research Progress in Forensic Toxicology.
Identifieur interne : 000149 ( Main/Exploration ); précédent : 000148; suivant : 000150The Trial of Chloroquine in the Treatment of Corona Virus Disease 2019 （COVID-19） and Its Research Progress in Forensic Toxicology.
Auteurs : Y J Duan [République populaire de Chine] ; Q. Liu [République populaire de Chine] ; S Q Zhao [République populaire de Chine] ; F. Huang [République populaire de Chine] ; L. Ren [République populaire de Chine] ; L. Liu [République populaire de Chine] ; Y W Zhou [République populaire de Chine]Source :
- Fa yi xue za zhi [ 1004-5619 ] ; 2020.
Abstract
Chloroquine is a long-established prescription drug that is often used clinically to treat malaria and connective tissue diseases. Since December 2019, COVID-19 （corona virus disease 2019） outbreaks caused by SARS-CoV-2 （severe acute respiratory syndrome coronavirus 2） has occurred in China and many countries around the world. Due to the lack of drugs against COVID-19, the disease spreads rapidly and the mortality rate is relatively high. Therefore, specific drugs against SARS-CoV-2 need to be quickly screened. The antimalarial drug Chloroquine phosphate which has already been approved is confirmed to have an anti-SARS-CoV-2 effect and has been included in diagnostic and therapeutic guidelines. However, awareness of the risk of chloroquine phosphate causing acute poisoning or even death should be strengthened. The dosage used according to current clinical recommended dosage and course of treatment are larger than that of previous treatment of malaria. Many provinces have required close clinical monitoring of adverse reactions. This paper reviews the pharmacological effects, poisoning and toxicological mechanisms, in vivo metabolism and distribution, and forensic issues of chloroquine drugs, in order to provide help to forensic practice and clinical work.
DOI: 10.12116/j.issn.1004-5619.2020.02.001
PubMed: 32212513
Affiliations:
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Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhou, Y W" sort="Zhou, Y W" uniqKey="Zhou Y" first="Y W" last="Zhou">Y W Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author></analytic><series><title level="j">Fa yi xue za zhi</title><idno type="ISSN">1004-5619</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chloroquine is a long-established prescription drug that is often used clinically to treat malaria and connective tissue diseases. Since December 2019, COVID-19 （corona virus disease 2019） outbreaks caused by SARS-CoV-2 （severe acute respiratory syndrome coronavirus 2） has occurred in China and many countries around the world. Due to the lack of drugs against COVID-19, the disease spreads rapidly and the mortality rate is relatively high. Therefore, specific drugs against SARS-CoV-2 need to be quickly screened. The antimalarial drug Chloroquine phosphate which has already been approved is confirmed to have an anti-SARS-CoV-2 effect and has been included in diagnostic and therapeutic guidelines. However, awareness of the risk of chloroquine phosphate causing acute poisoning or even death should be strengthened. The dosage used according to current clinical recommended dosage and course of treatment are larger than that of previous treatment of malaria. Many provinces have required close clinical monitoring of adverse reactions. This paper reviews the pharmacological effects, poisoning and toxicological mechanisms, in vivo metabolism and distribution, and forensic issues of chloroquine drugs, in order to provide help to forensic practice and clinical work.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement></list><tree><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Duan, Y J" sort="Duan, Y J" uniqKey="Duan Y" first="Y J" last="Duan">Y J Duan</name></region><name sortKey="Huang, F" sort="Huang, F" uniqKey="Huang F" first="F" last="Huang">F. Huang</name><name sortKey="Liu, L" sort="Liu, L" uniqKey="Liu L" first="L" last="Liu">L. Liu</name><name sortKey="Liu, Q" sort="Liu, Q" uniqKey="Liu Q" first="Q" last="Liu">Q. Liu</name><name sortKey="Ren, L" sort="Ren, L" uniqKey="Ren L" first="L" last="Ren">L. Ren</name><name sortKey="Zhao, S Q" sort="Zhao, S Q" uniqKey="Zhao S" first="S Q" last="Zhao">S Q Zhao</name><name sortKey="Zhou, Y W" sort="Zhou, Y W" uniqKey="Zhou Y" first="Y W" last="Zhou">Y W Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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